Local ERSPC protocol foresees:
1. |
Mail
invitation (males 55-70 years old). |
2. |
Upon
written informed consent - randomization 1:1 to active screening
or to control arm. |
3. |
PSA
determination in the active screening arm. |
4. |
If a) PSA is above 3ng/ml |
|
or
b) PSA is between 1-3 ng/ml and, additionally, free-to-total PSA
ratio below 20%:
Digital
rectal examination (DRE) and transrectal ultrasound (TRUS) guided
transrectal sextant biopsy (incl. DRE/TRUS lesion directed biopsy
if applicable) will be performed.
|
5. |
Otherwise
return to re-screening after 4 years and 8 years. |
The first screening
round started in September 1998 and the second screening round
started in
September 2002 accordingly, and is currently in course. Since 1998,
more
than 10,000 men have been randomized.
Local topics
of interest:
- New prostate tumor markers for detection and staging (human glandular
kallikrein 2–hK2)
- Value of free PSA for earlier prostate cancer detection.
- Evaluation of complex PSA (cPSA) for earlier prostate cancer detection.
- Performance of PSA-testing in various clinical settings.
- Performance of various PSA Assays.
- Quality of life after prostate cancer diagnosis and treatment.
|
