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Location:
Centro per lo Studio e la Prevenzione Oncologica (CSPO)
ISTITUTO SCIENTIFICO DELLA REGIONE TOSCANA
Viale A. Volta 171
50131 Florence
Italy
Contact address:
Stefano Ciatto MD
Centro per lo Studio e la Prevenzione Oncologica (CSPO)
Viale A. Volta 171, I-50131 Florence, Italy
Tel +39 055 5012214
Fax +39 055 5001623
e-mail s.ciatto@cspo.it
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Local ERSPC protocol foresees:
- randomisation
(1:1) of resident males 55-69
- invitation of
subjects allocated to active screening arm (call recall by mail)
- PSA (tandem
R - Hybritech) determination
- PSA <2.5
ng/ml: return to screening after 4 years
- PSA 2.5-3.9:
DRE + TRUS and directed biopsy to DRE/TRUS abnormalities
- PSA 4 >
: DRE, TRUS, and routine random sextant biopsy (transperineal
US guidied) + directed biopsy to DRE/TRUS abnormalities
- screening started
in October 1996: a total of 15,000 subjects have been randomised up
to October 2000 when second round started
- local focus of
interest
- selection
criteria for biopsy, to improve its positive predictive value
- determination
of opportunistic PSA in the control arm
- estimate
and determination of overdiagnosis magnitude
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